Incidence and In-Hospital Mortality of Neonatal Disseminated Intravascular Coagulation in Japan: An Observational Study of a Nationwide Hospital Claims Database

DOI IR Web Site Web Site PubMed 2 Citations 19 References
  • ARAKI Shunsuke
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
  • TOMIOKA Shinichi
    Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan
  • OTANI Makoto
    Occupational Health Data Science Center, School of Medicine, University of Occupational and Environmental Health, Japan
  • SUGA Shutaro
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
  • ICHIKAWA Shun
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
  • MATSUDA Shinya
    Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan Occupational Health Data Science Center, School of Medicine, University of Occupational and Environmental Health, Japan
  • FUSHIMI Kiyohide
    Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School
  • KUSUHARA Koichi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
  • SHIRAHATA Akira
    Kitakyushu Yahata Higashi Hospital

Bibliographic Information

Other Title
  • DPCデータを用いた日本における新生児DICの発生と院内死亡率

Search this article

Abstract

This study aimed to estimate the incidence and prognosis of neonatal disseminated intravascular coagulation (DIC) in Japan by analyzing data retrieved from a national administrative database. Clinically, the prognosis of DIC in neonates is poor, but there is little epidemiological data in Japan. This retrospective observational study identified patients diagnosed with neonatal DIC and who were registered in the Japanese diagnosis procedure combination (DPC) database between April 1, 2014 and March 31, 2016. The patients, who were diagnosed with neonatal DIC, included those with ICD-10 code D65 or P60 in primary and secondary diagnosis, with comorbid conditions existing at admission, and with complications occurring after admission. Of 78,073 neonates admitted to 1,474 neonatal intensive care units, 1,864 (2.4%) were diagnosed with DIC. There was no difference between sexes in incidence of DIC; the incidence of DIC was higher in extremely low birth weight infants (9.8%), and significantly higher than that in normal birth weight infants. The overall mean length of hospital stay was longer in neonates with DIC (69.5 days) than in those without DIC (32.6 days, P < 0.001). The number of deaths was 1,156 (1.5%). In-hospital mortality was significantly higher in neonates with DIC (14.1%) than in those without DIC (1.2%, P < 0.001), especially in premature babies. This nationwide study was the first report to investigate the incidence and in-hospital mortality of neonatal DIC in Japan. Neonatal DIC has a significant impact on prognosis, and its influence is greater in premature than in term infants.

Journal

  • Journal of UOEH

    Journal of UOEH 41 (3), 295-302, 2019-09-01

    The University of Occupational and Environmental Health, Japan

Citations (2)*help

See more

References(19)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top