Three Cases of Breast Cancer in a Family with Hereditary Breast and Ovarian Cancer Syndrome Undergoing Risk-reducing Salpingo-oophorectomy
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- NAGATSUKA Miki
- Department of Surgery, Hoshi General Hospital
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- MATSUZAKI Masami
- Department of Surgery, Hoshi General Hospital
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- KATAGATA Naoto
- Department of Surgery, Hoshi General Hospital
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- SAKUMA Takeshi
- Department of Surgery, Hoshi General Hospital
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- NIHEI Mitsuhiro
- Department of Surgery, Igarashi Internal Medicine and Surgery Clinic
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- NOMIZU Tadashi
- Department of Surgery, Hoshi General Hospital
Bibliographic Information
- Other Title
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- 乳癌発症3例にリスク低減卵管卵巣切除を施行した遺伝性乳癌卵巣癌家系
- 症例 乳癌発症3例にリスク低減卵管卵巣切除を施行した遺伝性乳癌卵巣癌家系
- ショウレイ ニュウガン ハッショウ 3レイ ニ リスク テイゲンランカン ランソウ セツジョ オ シコウ シタ イデンセイ ニュウガン ランソウ ガン カケイ
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Abstract
<p>We report three cases of BRCA2-related breast cancer within a family with hereditary breast and ovarian cancer syndrome (HBOC), in which risk-reducing salpingo-oophorectomy (RRSO) was performed. Two out of three sisters, including the proband, developed breast cancer, one had colon cancer, and their paternal cousin also developed metachronous bilateral breast cancer. The cousin's father (paternal uncle) was diagnosed with prostate cancer and his sister (paternal aunt), with ovarian cancer. Because of a family history suggestive of HBOC, the proband was subjected to BRCA genetic testing, revealing a deleterious germline mutation in BRCA2. The same deleterious mutation was confirmed in the sister and the cousin diagnosed with breast cancer. All three cases were luminal cancer and received mastectomy and endocrine therapy. As these three cases already had a genetic diagnosis of HBOC, RRSO was performed concomitantly with the surgical therapy for benign lesions in the uterus and was followed by endocrine therapy.</p>
Journal
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- Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 80 (3), 499-502, 2019
Japan Surgical Association
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Keywords
Details 詳細情報について
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- CRID
- 1390564227316736384
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- NII Article ID
- 130007720212
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- NII Book ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- NDL BIB ID
- 029635282
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed