Genome editing in human embryos: ethical concerns and practical applications

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  • AKUTSU Hidenori
    National Research Institute for Child Health and Development, Department of Reproductive Medicine

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  • ゲノム編集の治療応用と倫理的課題
  • ゲノム ヘンシュウ ノ チリョウ オウヨウ ト リンリテキ カダイ

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Abstract

<p>As genome editing techniques are developed, they have been applied to somatic cells in clinical use. Regarding the adaptation of these techniques in human zygotes, advances in single-cell analysis technology are expected to enhance knowledge at the molecular level, even in human preimplantation embryo development, and the application of genome editing technology for molecular functional analysis is expected. However, the use of genetic modification techniques on germlines, including zygotes, spreads to all cells of an individual and is subsequently passed down through generations. Here we explore the possibilities and challenges of applying genome editing techniques to better understand the scientific aspects of the human germline.</p>

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  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (9), 1033-1045, 2019

    The Japanese Society of Hematology

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