Rapidly developing preauricular malignant melanoma with dedifferentiation : A case report

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  • TAKAHASHI Saki
    Department of Dermatology, Yokohama City University School of Medicin
  • WADA Hidefumi
    Department of Dermatology, Yokohama City University School of Medicin
  • YAMAKAWA Kohei
    Department of Dermatology, Yokohama City University School of Medicin
  • ISHIKAWA Hideyuki
    Department of Dermatology, Yokohama City University School of Medicin
  • FUKUZAWA Rie
    Department of Dermatology, Yokohama City University School of Medicin
  • IKEDA Nobuaki
    Department of Dermatology, Yokohama City University School of Medicin
  • KANAOKA Miwa
    Department of Dermatology, Yokohama City University School of Medicin
  • KATO Ikuma
    Department of Pathology, Yokohama City University School of Medicine
  • OKUDERA Koji
    Department of Pathology, Yokohama City University School of Medicine
  • AIHARA Michiko
    Department of Dermatology, Yokohama City University School of Medicin

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Other Title
  • 脱分化を来し急速に増大した耳前部悪性黒色腫の1例

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<p>We report an 81-year-old man who developed malignant melanoma with dedifferentiation.</p><p>A purple-red tumor appeared in front of the patient’s left ear. It developed rapidly over several weeks. Hematoxylin and eosin staining of the biopsy specimens showed an alveolar-like structure in the dermis with proliferation of atypical cells of varying sizes. Immunostaining revealed positivity for Melan A, HMB45, and S100.</p><p>After 2 weeks, he was referred to our hospital and the tumor was removed. The size of the tumor was 50×40×30 mm. The histological examination showed proliferation of epithelial-like tumor cells, with weakly stained eosinophilic cytoplasm through hematoxylin and eosin staining. Immunostaining revealed negative results for the aforementioned melanocyte markers.</p><p>These findings were inconsistent with those of the biopsy.</p><p>Dedifferentiation of malignant melanoma is extremely rare and a relatively new concept. Therefore, it may be misdiagnosed as another sarcoma. Awareness of this concept is important for accurate diagnosis.[Skin Cancer (Japan) 2019 ; 34 : 144-148]</p>

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  • Skin Cancer

    Skin Cancer 34 (2), 144-148, 2019

    The Japanese Skin Cancer Society

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