A Case of Enzootic Bovine Leukosis in a Five-month-old Calf
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- WAKATSUKI Takuji
- Okayama Agricultural Mutual Relief Association, Hokubu Core Livestock Medical Office
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- SUGIYAMA Sadamu
- Okayama Agricultural Mutual Relief Association, Hokubu Core Livestock Medical Office
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- TAKAOKA Asako
- Okayama Agricultural Mutual Relief Association, Hokubu Core Livestock Medical Office
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- HASHIDA Akihiko
- Okayama Prefectural Ikasa Livestock Hygiene Service Center
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- MIZUKAMI Chiaki
- Okayama Prefectural Okayama Livestock Hygiene Service Center
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- HIROSE Yuri
- Okayama Prefectural Okayama Livestock Hygiene Service Center
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- KADOTA Koichi
- Hokkaido Research Station, National Institute of Animal Health
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- TAKESHIMA Shinnosuke
- RIKEN
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- AIDA Yoko
- RIKEN
Bibliographic Information
- Other Title
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- 若齢牛において地方病性牛白血病と診断した1例
- ジャクレイギュウ ニ オイテ チホウビョウセイギュウ ハッケツビョウ ト シンダン シタ 1レイ
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Abstract
<p>Although enzootic bovine leukosis (EBL) usually occurs in cattle over 4 years of age, a diagnosis of EBL was able to be established in a 5-month-old crossbred steer. This animal showed marked swelling of the superficial lymph nodes at 134 days old. At 168 days old, swelling of the superficial lymph nodes deteriorated. A blood examination revealed the rapid elevation of the white blood cell count (104,000/μl ) with 89% atypical lymphocytes. In the necropsy, the abdominal lymph nodes were greatly enlarged. Histologically, tumor cells characterized by pleomorphism and atypia showed proliferation or infiltration in lymph nodes and a variety of internal organs. Real-time PCR showed an extremely high number of copies of proviral bovine leukemia virus (BLV) in the peripheral blood and the lymph nodes examined. B cell clonality tests showed biclonality growth of tumor cells. A diagnosis of EBL was made based on these findings. Analysis of bovine leukocyte antigen (BoLA) genes, associated with the susceptibility to BLV, showed BoLA-DRB3<i></i>*1101 and *1601 ; therefore, multiple factors are thought to have been implicated in the neoplastic transformation in the present case.</p>
Journal
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- Journal of the Japan Veterinary Medical Association
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Journal of the Japan Veterinary Medical Association 72 (10), 608-613, 2019-10-20
Japan Veterinary Medical Association
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Details 詳細情報について
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- CRID
- 1390564227347955712
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- NII Article ID
- 130007748704
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- NII Book ID
- AN00191857
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- ISSN
- 21860211
- 04466454
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- NDL BIB ID
- 030039243
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed