Quantitative Bio-imaging of Gadolinium-157 in Tissues Through Laser-ablation ICP-MS for Neutron Capture Therapy
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- KUBOTA AYANO
- Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine
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- MATSUKAWA TAKEHISA
- Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine Department of Forensic Medicine, Juntendo University Faculty of Medicine
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- YANAGIE HIRONOBU
- Department of Nuclear Engineering and Management, The University of Tokyo
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- YANAGAWA MASASHI
- Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
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- HIRATA TAKAFUMI
- Geochemical Research Center, The University of Tokyo
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- SHINOHARA ATSUKO
- Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine Research Institute for Cultural Studies, Seisen University
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- YOKOYAMA KAZUHITO
- Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine Department of Epidemiology and Social Medicine, International University of Health and Welfare Graduate School of Public Health
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Abstract
<p>Objective: Gadolinium-157 (157Gd) has attracted interest for its use in the preparation containing metal elements of the neutron capture therapy (NCT), one of the radiation therapies. The study, however, has not developed because of the difficulty to quantify the concentration of 157Gd in the tissue. Therefore, we established a quantitative imaging technique for 157Gd in bio-tissue employing laser-ablation inductively coupled mass spectrometry (LA-ICP-MS).</p><p>Materials and Methods: 4 female New Zealand white rabbits, which were inoculated with rabbit VX-2 cells participated in this study. 157Gd in water-in-oil-in-water (WOW) emulsion was injected via the proper hepatic artery into the rabbits and, after 24 or 72 hours, the rabbits were killed, and the liver tissues were harvested. We also prepared 7 standard tissues which were mixed with gadoteridol solutions, the final amount of 157Gd was 0, 4.4, 22, 44, 220, 440 and 660 μg/g, respectively. The harvested livers and standards were sectioned on a cryostat at 5 μm intervals and they were analyzed by LA-ICP-MS.</p><p>Result: In an experiment on animal cancer tissue, 157Gd was observed to accumulate around the cancer.</p><p>Conclusion: The 157Gd concentration in bio tissue can be quantitatively assessed through LA-ICP-MS imaging and it was expected to contribute the progress of NCT study.</p>
Journal
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- Juntendo Medical Journal
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Juntendo Medical Journal 65 (5), 461-467, 2019
The Juntendo Medical Society
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Keywords
Details 詳細情報について
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- CRID
- 1390564227351719040
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- NII Article ID
- 130007752696
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- NII Book ID
- AA1262207X
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- ISSN
- 21882126
- 21879737
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- NDL BIB ID
- 030158038
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed