Action of Calcitonin Gene-related Peptide and Mechanisms of Postoperative Pain Compared with Inflammatory Pain

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  • ISHIDA Kumiko
    Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine
  • KAWAMATA Mikito
    Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine

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  • カルシトニン遺伝子関連ペプチドの作用から考える術後痛モデルのメカニズム─炎症性疼痛モデルと比較して─

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Abstract

<p>Nociceptive stimuli reach the brain from peripheral sites of surgical injury through the spinal cord. Optimization of postoperative pain treatment may not only lead to increased patient comfort but may also reduce complications, improve perioperative outcome, and prevent prolonged pain. The role of calcitonin gene-related peptide has recently been reported to be more important than the role of substance P in transmission and modification of pain, but the mechanisms by which these peptides transmit and modify nociceptive pain are not clear. In this paper, we discuss the mechanisms of postoperative pain compared with inflammatory pain in animal models.</p>

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