Chromosomal Rearrangement: From Induction by Heavy-Ion Irradiation to <i>in Vivo</i> Engineering by Genome Editing
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- Kazama Yusuke
- Mutation Genomics Team, Nishina Center for Accelerator-Based Science, RIKEN
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- Hirano Tomonari
- Faculty of Agriculture, University of Miyazaki Ion Beam Breeding Team, Nishina Center for Accelerator-Based Science, RIKEN
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- Abe Tomoko
- Ion Beam Breeding Team, Nishina Center for Accelerator-Based Science, RIKEN
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- Matsunaga Sachihiro
- Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
説明
<p>Chromosomal rearrangements are thought to play a role in speciation, adaptation and evolution. The effects of chromosomal rearrangements on gene expression have been reported in many species and their close relatives, and may illustrate the consequences of adaptation. To investigate the effects of chromosomal rearrangements on phenotypic changes directly, studies of experimentally induced rearrangements are required; they allow gene expression and epigenetic states to be compared between mutants and wild-types. We have developed an effective method for inducing chromosomal rearrangements with heavy-ion beam irradiation, which is a sort of ionizing radiation. Reconstruction of such rearrangements by genome editing will enable reproducible studies on the effects of chromosomal rearrangements. In the future, therefore, these techniques will usher in a new era in which researchers can create novel species with designer chromosomes.</p>
収録刊行物
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- CYTOLOGIA
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CYTOLOGIA 83 (2), 125-128, 2018-06-25
公益財団法人 日本メンデル協会
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詳細情報 詳細情報について
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- CRID
- 1390564237996120576
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- NII論文ID
- 130007394032
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- ISSN
- 13487019
- 00114545
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可