- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Determination of the cytologic features of medullary thyroid carcinoma
-
- MARUTA Junko
- Department of Pathology, Noguchi Thyroid Hospital and Foundation
-
- HIROKAWA Mitsuyoshi
- Department of Diagnostic Pathology and Cytology, Kuma Hospital
-
- SASAKI Eiji
- Department of Laboratory, Ito Hospital
-
- KOSHIKAWA Takashi
- Department of Pathology, Shubun University Faculty of Nursing
-
- KATOH Ryohei
- Department of Pathology, University of Yamanashi
-
- SAKAMOTO Atsuhiko
- Department of Laboratory Medicine, Omori Red Cross Hospital
Bibliographic Information
- Other Title
-
- 甲状腺髄様癌の細胞診断学的特徴の究明
Search this article
Description
<p>Objective : We examined the cytological features of medullary carcinoma (MC) of the thyroid gland, including the nuclear dimensions, in order to identify useful diagnostic features for MC that are unlikely to be beset by errors arising from inter-examiner differences, and propose a diagnostic algorithm for improvement of the diagnosis rate.</p><p>Study Design : Using cytological specimens obtained from 78 cases of MC, 20 cases of papillary carcinoma, 20 cases of follicular carcinoma and 20 cases of poorly differentiated carcinoma of the thyroid gland, we compared the rates of detection of salt and pepper chromatin, nuclear grooves, nuclear cytoplasmic inclusion bodies and multinucleated carcinoma cells, the amyloid and nuclear areas, the nuclear aspect ratio (ratio of the major axis diameter to minor axis diameter?), and the long diameter of the nuclei in order to identify features useful for the diagnosis of MC.</p><p>Results : Diagnosis of MC was confirmed in 59 cases. It was estimated by logistic regression analysis in a further 7 cases. Based on our findings, we suggest the following as useful features for the diagnosis of MC : 1) salt and pepper appearance of the nuclear chromatin ; 2) 4 or more multinucleated carcinoma cells ; 3) presence of amyloid ; 4) nuclear aspect ratio≥1.6 ; 5) CV of the nuclear aspect ratio≥25%, 6) ratio between the minimum and maximum longest diameters of the nuclei≥3.7.</p><p>Conclusion : Among the 78 specimens of MC, the diagnosis could be made by cytologic examination in 66 cases (84.6%).</p>
Journal
-
- The Journal of the Japanese Society of Clinical Cytology
-
The Journal of the Japanese Society of Clinical Cytology 57 (3), 151-158, 2018
The Japanese Society of Clinical Cytology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390564237996865536
-
- NII Article ID
- 130007403805
-
- ISSN
- 18827233
- 03871193
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
-
- Abstract License Flag
- Disallowed