SENSITIVITY OF FRUIT-SPECIFIC IgE SCREENING IN MULTI-PANEL ANTIBODY TESTING

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  • Fukutomi Yuma
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
  • Minami Takafumi
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
  • Taniguchi Masami
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

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Other Title
  • 特異的IgE 抗体同時多項目測定検査における果物特異的IgE抗体の感度
  • トクイテキ IgE コウタイ ドウジ タコウモク ソクテイ ケンサ ニ オケル クダモノ トクイテキ IgE コウタイ ノ カンド

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Abstract

<p>Background: One of the strengths of multi-panel IgE testing is that it facilitates screening for IgE antibodies (Abs) in allergic patients by providing data on levels of IgE Abs to multiple allergens at the same time. Nonetheless, its diagnostic sensitivity for clinical use has not been well-studied.</p><p>Methods: We tested sera from 33 fruit-allergic patients. The sensitivity of determining IgE Abs to fruit allergens using the MAST Immunosystems (MAST) system and the View Allergy 39 (VA) system was calculated separately in patients sensitized to PR-10 or to profilin, and compared with that of single-panel IgE testing (ImmunoCAP system).</p><p>Results: In both the PR-10 sensitized and 31 profilin sensitized groups, the sensitivity of the IgE Abs to apple measured by VA (87%, and 83%, respectively) was almost identical to that of ImmunoCAP. On the other hand, the sensitivity of IgE Abs to peach measured by MAST (23% and 25%, respectively) was markedly lower than that of ImmunoCAP.</p><p>Conclusions: The sensitivity of fruit IgE Abs in the MAST system was remarkably lower than that of the ImmunoCAP system. Caution is necessary in clinical practice when interpreting of the results of some multipanel IgE testing.</p>

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