Comparison of personal air benzene and urine t,t-muconic acid as a benzene exposure surrogate during turnaround maintenance in petrochemical plants
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- KOH Dong-Hee
- Department of Occupational and Environmental Medicine, International St. Mary’s Hospital, Catholic Kwandong University, Korea
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- LEE Mi-Young
- Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Korea
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- CHUNG Eun-Kyo
- Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Korea
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- JANG Jae-Kil
- Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Korea
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- PARK Dong-Uk
- Department of Environmental Health, Korea National Open University, Korea
書誌事項
- タイトル別名
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- Comparison of personal air benzene and urine <i>t,t</i>-muconic acid as a benzene exposure surrogate during turnaround maintenance in petrochemical plants
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<p>Previous studies have shown that biomarkers of chemicals with long half-lives may be better surrogates of exposure for epidemiological analyses, leading to less attenuation of the exposure-disease association, than personal air samples. However, chemicals with short half-lives have shown inconsistent results. In the present study, we compared pairs of personal air benzene and its short-half-life urinary metabolite trans,trans-muconic acid (t,t-MA), and predicted attenuation bias of theoretical exposure-disease association. Total 669 pairs of personal air benzene and urine t,t-MA samples were taken from 474 male workers during turnaround maintenance operations held in seven petrochemical plants. Maintenance jobs were classified into 13 groups. Variance components were calculated for personal air benzene and urine t,t-MA separately to estimate the attenuation of the theoretical exposure-disease association. Personal air benzene and urine t,t-MA showed similar attenuation of the theoretical exposure-disease association. Analyses for repeated measurements showed similar results, while in analyses for values above the limits of detection (LODs), urine t,t-MA showed less attenuation of the theoretical exposure-disease association than personal air benzene. Our findings suggest that there may be no significant difference in attenuation bias when personal air benzene or urine t,t-MA is used as a surrogate for benzene exposure.</p>
収録刊行物
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- Industrial health
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Industrial health 56 (4), 346-355, 2018
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390564237999503360
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- NII論文ID
- 130007420242
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- NII書誌ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 029138412
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- PubMed
- 29643270
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可