Physiological and Pathophysiological Roles of Transient Receptor Potential Channels in Microglia-Related CNS Inflammatory Diseases
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- Shirakawa Hisashi
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Kaneko Shuji
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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<p>Central nervous system (CNS) inflammation is a potential therapeutic target for neurodegenerative diseases. In recent years, a number of studies have focused on the links between neurodegenerative diseases and CNS glial cells, especially microglia. Microglia are the main resident immune cells in the CNS and represent approximately 10–15% of all CNS cells. Microglia play an important role in maintaining brain homeostasis at rest by surveying the environment, and engulfing apoptotic cells and debris in the healthy brain. However, under certain pathological conditions, microglia can generate neurotoxic factors, such as pro-inflammatory cytokines and molecules like nitric oxide (NO), which lead to CNS inflammatory diseases. In this review, we discuss the evidence that regulation of microglial ion channels may modulate CNS inflammation and subsequent tissue damage in neurological disorders. In particular, we discuss the role of transient receptor potential (TRP) channels in microglia in both acute and chronic inflammatory conditions, and describe the physiological and pathophysiological roles of TRP channels in CNS inflammatory pathways. Additionally, we describe the benefits of stimulation/inhibition of TRP channels in animal models of microglia-related CNS inflammatory diseases.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 41 (8), 1152-1157, 2018-08-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390564238002992128
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- NII論文ID
- 130007428756
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 2433/241621
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- NDL書誌ID
- 029115868
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- PubMed
- 30068863
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- 本文言語コード
- en
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- データソース種別
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- IRDB
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- PubMed
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