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- 冨田 正浩
- 株式会社免疫生物研究所遺伝子組換えカイコ事業部
書誌事項
- タイトル別名
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- Development of Large Scale Silkworm-rearing Technologies for the GMP Production of Biologics
- Symposium Review バイオ医薬品製造に向けたGMP組換えカイコの大量飼育技術開発
- Symposium Review バイオ イヤクヒン セイゾウ ニ ムケタ GMP クミカエ カイコ ノ タイリョウ シイク ギジュツ カイハツ
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There exists an increasing need to produce useful proteins in recombinant technologies. In particular, most biologics for medical purposes are produced as recombinant proteins. Various host cell/vector systems have been developed, but it remains difficult to efficiently produce large molecular weight proteins with complex structures. As a result of breeding for several thousand years, the silkworm has acquired the ability to synthesize bulk amounts of silk proteins. To utilize this capacity for the mass production of useful proteins, transgenic silkworms have been generated that synthesize recombinant proteins in the silk gland and secrete them into the silk cocoon. Using this transgenic silkworm system, various proteins, including antibodies, collagen, and fibrinogen, have been successfully produced and are being developed as materials for diagnostic or research-use reagents, as well as for cosmetics. Moreover, several silkworm-produced proteins are being developed as biologics for therapeutic use. Transgenic silkworms need to be reared under good manufacturing practices (GMP)-compliant conditions to produce biologics. Therefore, we have constructed a GMP-compliant pilot plant for producing biologics using transgenic silkworm, and are now developing silkworm-rearing technology under GMP-compliant conditions.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 138 (7), 875-884, 2018-07-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390564238016763520
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- NII論文ID
- 130007386699
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 029150233
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- PubMed
- 29962463
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可