General Principles and Recent Advances of Antedrug/Soft Drug

DOI
  • Imai Teruko
    Faculty of Pharmaceutical Sciences, Kumamoto University

Bibliographic Information

Other Title
  • アンテドラッグ/ソフトドラッグのドラッグデザインの実例と展望

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Description

<p>The “antedrug” or “soft” drug have been designed to exert their desired effect locally but these drugs are inactivated in the circulation to reduce unwanted systemic effects. The ideal antedrug should combine stability in the target tissue with very rapid inactivation into predictable metabolite in the systemic circulation. The metabolic consideration should be an integral part of the drug design process and that this process should focus not on improving activity alone, but also on improving the therapeutic index. Here, the concept of “antedrug” and “soft” drug has been explained and then metabolic enzymes for rapid inactivation and their species difference were shown. Finally, the several examples of “antedrug” and “soft” drug were presented according to the different approach for the design of antedrug.</p>

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 25 (4), 207-213, 2015-11-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390564238017534720
  • NII Article ID
    130007480823
  • DOI
    10.14894/medchem.25.4_207
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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