Molecular Investigations of the Development and Diseases of Cerebral Cortex Folding using Gyrencephalic Mammal Ferrets
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- Kawasaki Hiroshi
- Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University
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抄録
<p>Folds of the cerebral cortex (gyri and sulci) are among the most important properties of the mammalian brain. Uncovering the physiological roles, developmental mechanisms and evolution of the cortical folds would greatly facilitate our understanding of the human brain and its diseases. Although the anatomical features of the cortical folds have been intensively investigated, our knowledge about their molecular bases is still limited. To overcome this limitation, we recently established rapid and efficient genetic manipulation techniques for the brain of gyrencephalic mammal ferrets (Mustela putorius furo). Using these techniques, we successfully uncovered the molecular mechanisms of cortical folding. In this article, I will summarize our recent research on the molecular mechanisms of development and diseases of cortical folding.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 41 (9), 1324-1329, 2018-09-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390564238018940032
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- NII論文ID
- 130007479897
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029184894
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- PubMed
- 30175769
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可