The Surge in the Number of Circulating Tumor Cells Following Treatment with Sunitinib for Metastatic Renal Cell Carcinoma

  • Nagaya Naoya
    Department of Urology, Juntendo University Graduate School of Medicine, Japan
  • Kanayama Mayuko
    Department of Urology, Juntendo University Graduate School of Medicine, Japan
  • Nagata Masayoshi
    Department of Urology, Juntendo University Graduate School of Medicine, Japan
  • Horie Shigeo
    Department of Urology, Juntendo University Graduate School of Medicine, Japan

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Abstract

<p>Circulating tumor cells (CTCs) are a promising biomarker for several cancers. We streamlined the experimental procedure of CTC immunofluorescent staining. We encountered a 72-year-old woman with metastatic right renal cell carcinoma (RCC) (clinical stage: T4N0M1), whose CTC number rapidly increased after the administration of sunitinib and then gradually decreased. The change in the CTC number appeared to coincide with laboratory data and hypertension, suggesting that a CTC analysis may be useful for promptly monitoring the treatment response. Our data provided the first evidence of an association between the CTC numbers and the treatment response in a metastatic RCC patient. </p>

Journal

  • Internal Medicine

    Internal Medicine 57 (18), 2695-2700, 2018-09-15

    The Japanese Society of Internal Medicine

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