A case of multiple cerebral hemorrhage caused by sudden increase of eosinophil in a patient with eosinophilic granulomatosis with polyangiitis
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- Yamada Yumi
- Department of Neurology, Nagaoka Red Cross Hospital
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- Ando Shoichiro
- Department of Neurology, Nagaoka Red Cross Hospital
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- Umeda Yoshitaka
- Department of Neurology, Nagaoka Red Cross Hospital
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- Umeda Maiko
- Department of Neurology, Nagaoka Red Cross Hospital
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- Oyake Mutsuo
- Department of Neurology, Nagaoka Red Cross Hospital
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- Fujita Nobuya
- Department of Neurology, Nagaoka Red Cross Hospital
Bibliographic Information
- Other Title
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- 好酸球増多を契機に多発脳出血をきたした好酸球性多発血管炎性肉芽腫症の1例
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Description
<p>A 42-year-old woman with bronchial asthma was admitted to our hospital due to sensory dominant mononeuritis multiplex lasting for more than 6 months. At that time, her eosinophil count was 761/μl and her sural nerve biopsy showed no findings suggestive of vasculitis. Four months later, she experienced sudden convulsions and right hemiparesis due to left lobular parietal subcortical hemorrhage, when her eosinophil count was elevated to 3,257/μl. Numerous microbleeds and small infarctions were also detected in the intracerebral areas of different regions with MRI. Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis of the small vessels, commonly affecting the peripheral nerves. Subarachnoid hemorrhage in patients with EGPA is extremely rare. Steep elevation of the eosinophil count may release certain cytokines, causing cerebral hemorrhage.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 58 (9), 565-569, 2018
Societas Neurologica Japonica
