Positions and numbers of hydroxyl groups in hydroxychalcone derivatives are involved in cytotoxicity against human monoblastic U937 cells

DOI Web Site 被引用文献2件 参考文献17件 オープンアクセス

この論文をさがす

説明

<p>Hydroxychalcone derivatives belonging to polyphenol group, and distributed throughout the plant kingdom, can behave as anti-cancer agents due to their cytotoxic activities. Hydroxychalcone derivatives also have the potential as chemotherapeutic drugs for cancer. In this paper, we revealed that positions and numbers of hydroxyl groups in hydroxychalcones are involved in cytotoxicity against human monoblast U937 cells. Interestingly, 2-hydroxychalcone remarkably reduced viability of U937 cells as compared to chalcone, 2’-hydroxychalcone, 4-hydroxychalcone, and 4’-hydroxychalcone. In addition, 2’, 4, 4’-trihydroxychalcone showed stronger cytotoxicity than 2’-hydroxychalcone, 2’, 4-dihydroxychalcone, and 2’, 4’-dihydroxychalcone. These results demonstrate that positions and numbers of hydroxyl groups in hydroxychalcones are involved in cytotoxicity against U937 cells. Moreover, we showed that all-trans retinoic acid-induced differentiation of U937 cells brought about an enhanced resistance against some cytotoxic hydroxychalcone derivatives. These data suggest that hydroxychalcone derivatives in combination with all-trans retinoic acid could serve as effective modifiers in therapy for leukemia.</p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (17)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ