Omega-3 polyunsaturated fatty acids reduce the risk of cardiovascular events in the patients with ischemic heart disease and heart failure

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  • Takashima Akira
    Department of Cardiology, Tokushima Prefecture Naruto Hospital
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School

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Other Title
  • 特集　ここまで明らかになったω3脂肪酸　「ω3系不飽和脂肪酸による虚血性心疾患や心不全患者の 心血管イベントリスクの軽減」
  • ω3系不飽和脂肪酸による虚血性心疾患や心不全患者の心血管イベントリスクの軽減
  • o3ケイ フホウワ シボウサン ニ ヨル キョケツセイシン シッカン ヤ シンフゼン カンジャ ノ シンケッカン イベントリスク ノ ケイゲン

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Description

Accumulating evidence has demonstrated that omega-3 polyunsaturated fatty acids, the major components of fish oil, reduce the risk of cardiovascular diseases. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the major components of omega-3 polyunsaturated fatty acids which reduce atherogenesis, which contributes to the prevention of cardiovascular events in patients with ischemic heart disease. Omega-3 polyunsaturated fatty acids have been reported to improve left ventricular systolic function and functional capacity and to reduce mortality and hospitalization for cardiovascular reasons in patients with heart failure or non-ischemic dilated cardiomyopathy. Although recent studies have demonstrated several molecular mechanisms of anti-inflammatory effects of omega-3 polyunsaturated fatty acids, the mechanism by which omega-3 polyunsaturated fatty acids reduce cardiovascular events remains to be elucidated.

Journal

  • VITAMINS

    VITAMINS 91 (9), 542-546, 2017

    THE VITAMIN SOCIETY OF JAPAN

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