Distribution of Fat Droplets in Liver Tissue of Rats Fed a Diet with Different Fatty Acid Compositions

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  • HOSOYAMADA Yasue
    Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences
  • YAMADA Masako
    Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences

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  • 脂肪酸組成の異なる油脂を摂取したラットの肝臓組織における脂肪滴の分布
  • シボウサン ソセイ ノ コトナル ユシ オ セッシュ シタ ラット ノ カンゾウ ソシキ ニ オケル シボウ テキ ノ ブンプ

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Abstract

Objectives: We examined the effect of oil intake differing in fatty acid composition on fat accumulation amount, concentration of serum and fat droplets adipocytes of liver tissue in rats. Methods: Young male rats were fed a high cholesterol diet containing either lard, soybean oil, perilla oil or fish oil for 4wk. The control diet contained a lard component. Results: Posterior abdominal wall fat and testicle peripheral fat weights were significantly lower in the fish oil group compared with the control and the soybean oil group. The number of fat droplets was significantly higher in the liver tissue of rats in the perilla oil group compared with the other groups, and many fat droplets with small diameters were observed. The proportion of fat droplets to the total area was significantly lower in the perilla oil group and the fish oil group compared with the control and the soybean oil group. Conclusion: The results suggested that oil intake differing in fatty acid composition correlates with fat accumulation amount and lipid droplet area in the liver tissue. Fish oil intake correlated with reduced visceral fat accumulation and is expected to be useful in the prevention and improvement of obesity.

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