CEREBRAL VENOUS SINUS THROMBOSIS IN PATIENTS WITH METASTATIC TESTICULAR CANCER DURING CHEMOTHERAPY: REPORTS OF TWO CASES
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- Kuboki Yuya
- Department of Urology, Yamagata University Faculty of Medicine
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- Yamagishi Atsushi
- Department of Urology, Yamagata University Faculty of Medicine
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- Kurokawa Masayuki
- Department of Urology, Yamagata University Faculty of Medicine
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- Kikuta Masato
- Department of Urology, Yamagata University Faculty of Medicine
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- Takai Satoshi
- Department of Urology, Yamagata University Faculty of Medicine
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- Takai Yuki
- Department of Urology, Yamagata University Faculty of Medicine
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- Ushijima Masaki
- Department of Urology, Yamagata University Faculty of Medicine
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- Kurota Yuta
- Department of Urology, Yamagata University Faculty of Medicine
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- Yagi Mayu
- Department of Urology, Yamagata University Faculty of Medicine
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- Sakurai Toshihiko
- Department of Urology, Yamagata University Faculty of Medicine
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- Nishida Hayato
- Department of Urology, Yamagata University Faculty of Medicine
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- Shibasaki Tomohiro
- Department of Urology, Yamagata University Faculty of Medicine
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- Kawazoe Hisashi
- Department of Urology, Yamagata University Faculty of Medicine
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- Ichiyanagi Osamu
- Department of Urology, Yamagata University Faculty of Medicine
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- Kato Tomoyuki
- Department of Urology, Yamagata University Faculty of Medicine
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- Nagaoka Akira
- Department of Urology, Yamagata University Faculty of Medicine
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- Tsuchiya Norihiko
- Department of Urology, Yamagata University Faculty of Medicine
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- Konno Yoshihiro
- Department of Diagnositic Radiology, Yamagata University Faculty of Medicine
Bibliographic Information
- Other Title
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- 精巣腫瘍化学療法中に脳静脈洞血栓症を発症した2例
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Abstract
<p>Cerebral venous sinus thrombosis (CVT) is rare but sometimes develops in association with malignant neoplasm. We report two cases of CVT that occurred during cisplatin-based chemotherapy for testicular cancer. A 46-year-old man with stage IIA non-seminomatous germ cell tumour was treated with conventional doses of etoposide and cisplatin (EP). On day 11 of the third treatment course, he developed a systemic seizure. Brain computed tomography (CT) and magnetic resonance (MR) imaging could not detect the cause. Enhanced chest-pelvic CT revealed pelvic thrombosis. Administration of phenytoin for epilepsy of unknown cause and heparin for thrombosis was started. He had completed 4 courses of EP therapy without seizure recurrence. After re-evaluating the brain CT images retrospectively, we found high density of superior sagittal sinus (SSS) and strongly suspected CVT. Another patient was a 47-year-old man with stage IIIB seminomatous germ cell tumour treated with bleomycin, etoposide, and cisplatin (BEP) therapy. On day 11 of the second treatment course, he developed a systemic seizure. Brain CT revealed subarachnoid haemorrhage localised in the right parietal lobe. CT venography revealed a filling defect in the superior sagittal sinus (SSS). MR venography revealed a SSS stenosis. We diagnosed the cause of the seizure as CVT and started administration of anticoagulant therapy. After the thrombus had diminished, chemotherapy was restarted and another 2 courses of BEP therapy was completed.</p>
Journal
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- The Japanese Journal of Urology
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The Japanese Journal of Urology 108 (4), 225-228, 2017-10-20
THE JAPANESE UROLOGICAL ASSOCIATION