Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia : China, Japan, Korea, and Taiwan
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- Hagiwara Daisuke
- Faculty of Life and Environmental Sciences, University of Tsukuba Medical Mycology Research Center, Chiba University
書誌事項
- タイトル別名
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- Current Status of Azole-resistant <i>Aspergillus fumigatus</i> Isolates in East Asia
- China, Japan, Korea, and Taiwan
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抄録
Aspergillus fumigatus is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are widely used for the management and prophylaxis of aspergillosis. An emerging issue is the increasing incidence of resistant isolates worldwide. In particular, environmentally derived tandem-repeat-type azole-resistant mutations, such as Cyp51A TR34/L98H, and Cyp51A TR46/Y121F/T289A, have emerged over the last decade. In particular, azole-resistant isolates were prevalent in clinical settings in European countries; many of the reports are from the Netherlands, UK, and Germany. In contrast, reports on azole-resistant A. fumigatus isolates from East Asian countries are still few and have only recently begun to increase. Herein, all literature on East Asian azole-resistant A. fumigatus isolates were reviewed, and a complete list of resistant isolates from China, Japan, Taiwan, and Korea is provided. As of this report, the total numbers of tandem-repeat-type azole-resistant isolates are 26, 3, 32, and 1 in China, Japan, Taiwan, and Korea, respectively.
収録刊行物
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- Medical Mycology Journal
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Medical Mycology Journal 59 (4), E71-E76, 2018
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詳細情報
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- CRID
- 1390564238048875392
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- NII論文ID
- 130007538271
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- NII書誌ID
- AA12518136
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- ISSN
- 2186165X
- 18820476
- 21856486
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- NDL書誌ID
- 029341581
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- PubMed
- 30504618
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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