Small-dense LDL Cholesterol is Associated with Insulin Resistance in BMI <30 kg/m<sup>2</sup>, Non-diabetic Japanese Population
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- Moriyama Kengo
- Department of Clinical Health Science, Tokai University School of Medicine
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- Takahashi Eiko
- Department of Clinical Health Science, Tokai University School of Medicine
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説明
<p>Aims: Small-dense low-density lipoprotein (sdLDL) and malondialdehyde LDL (MDA-LDL) are considered more atherogenic than LDL. However, information on the major determinants of sdLDL cholesterol (sdLDL-C) and MDA-LDL levels in Japanese subjects without diabetes is limited.</p><p>Methods: This study included 870 non-diabetic subjects with a body mass index (BMI) <30 kg/m2. All subjects underwent an annual health check-up that included sdLDL-C and MDA-LDL analyses. </p><p>Results: When subjects were stratified into four groups according to homeostasis model assessment of insulin resistance (HOMA-IR), sdLDL-C and MDA-LDL levels increased significantly, relative to the reference, with increasing HOMA-IR values, whereas LDL-C levels showed no consistent increase with increasing HOMA-IR. Multiple linear regression and logistic regression analyses revealed that LDL-C and triglyceride (TG) levels were major determinants of sdLDL-C levels, whereas LDL-C, sdLDL-C and high-density lipoprotein cholesterol (HDL-C) levels were major determinants of MDA-LDL levels. </p><p>Conclusions: Our data suggest that an increase in the LDL-C level and insulin resistance may lead to an increase in sdLDL-C levels and that increases in the LDL-C and sdLDL-C levels may lead to an increase in MDA-LDL in Japanese subjects without diabetes.</p>
収録刊行物
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- Ningen Dock International
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Ningen Dock International 4 (2), 81-88, 2017
公益社団法人 日本人間ドック学会
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詳細情報 詳細情報について
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- CRID
- 1390564238051234816
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- NII論文ID
- 130007528647
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- ISSN
- 21878080
- 21878072
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可