L-carnitine Improved the Cardiac Function via the Effect on Myocardial Fatty Acid Metabolism in a Hemodialysis Patient
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- Kaneko Mai
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan
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- Fukasawa Hirotaka
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan
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- Ishibuchi Kento
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan
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- Niwa Hiroki
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan
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- Yasuda Hideo
- First Department of Medicine, Hamamatsu University School of Medicine, Japan
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- Furuya Ryuichi
- Renal Division, Department of Internal Medicine, Iwata City Hospital, Japan
説明
<p>Patients on hemodialysis often have carnitine deficiency. We herein report a woman who experienced the dramatic improvement of cardiac dysfunction after intravenous L-carnitine administration. We also investigated the myocardial fatty acid metabolism using 123I-labeled β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT) before and after L-carnitine therapy, and the impaired metabolism was ameliorated. Taken together, these findings indicate that L-carnitine therapy improved cardiac dysfunction via the amelioration of the abnormal myocardial fatty acid metabolism, at least in part. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 57 (24), 3593-3596, 2018-12-15
一般社団法人 日本内科学会
