siRNA delivery systems for skin disorders treatment

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  • Takashima Yuuki
    Lab. of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • Ibaraki Hisako
    Lab. of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • Kanazawa Takanori
    Lab. of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Lab. of Pharmaceutics, School of Pharmacy, Nihon University

Bibliographic Information

Other Title
  • 皮膚疾患治療に向けたsiRNA送達システム
  • ヒフ シッカン チリョウ ニ ムケタ siRNA ソウタツ システム

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Description

<p>In recent years, there is a growing need for nucleic acid medicines targeting intractable skin diseases such as atopic dermatitis. Human skin is an available organ with the largest surface area for noninvasive drug administration. However, the intradermal permeability of hydrophilic and high molecular weight substances such as siRNA is strongly limited by the barrier function of the skin. Here, we introduce the siRNA delivery researches for skin disease treatment.</p>

Journal

  • Drug Delivery System

    Drug Delivery System 33 (4), 285-292, 2018-09-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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