Treatment of skin diseases applying the microneedle technology

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  • Hirobe Sachiko
    Advanced Research of Medical and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Osaka University Project of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
  • Okada Naoki
    Project for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Vaccine and Immune Regulation（BIKEN）, Graduate School of Pharmaceutical Sciences, Osaka University

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Other Title
  • マイクロニードルを用いた皮膚疾患治療
  • マイクロニードル オ モチイタ ヒフ シッカン チリョウ

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Abstract

<p>Seborrheic keratosis is characterized as sharply demarcated brownish plaques with verrucous surfaces. This lesion is considered unattractive and disfiguring and may have negative psychological impacts. Thus, they are often removed for cosmetic reasons by surgical treatments, such as cryotherapy and laser surgery. However, these treatments require regular outpatient treatments for complete removal of the lesions, incurring high costs. Drug therapy for seborrheic keratosis is an attractive treatment option for self-treatment at home but is not well established, because skin permeability of candidate ingredients for seborrheic keratosis is relatively low by keratinaization of stratum corneum. In this review, we introduce the development of a novel drug therapy using a self-dissolving microneedle patch which can directly deliver candidate ingredients to the epidermis by puncturing the stratum corneum.</p>

Journal

  • Drug Delivery System

    Drug Delivery System 33 (4), 293-302, 2018-09-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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