Assessment of Sarcopenia by Using Ultrasonographic Imaging of Leg Muscles: The Relationships Between Sarcopenia, Deep Vein Thrombosis, and Inflammatory Markers

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  • 下肢筋の超音波画像によるサルコペニア評価—サルコペニアと深部静脈血栓症および炎症マーカーとの関連性—

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Abstract

<p>Objective. Sarcopenia has been defined as the loss of muscle mass and the reduction of strength that usually progresses with aging. Meanwhile, deep vein thrombosis (DVT) is a common disease associated with high rates of mortality and morbidity. The present study was aimed at evaluating the imaging features of the gastrocnemius muscle (GM) by using sonography and investigating the relationships between sarcopenia and DVT and between sarcopenia and inflammatory markers.</p><p>Methods. Seventy-two patients who underwent sonographic examinations of their lower limbs for DVT screenings were enrolled in this study. We included 144 lower limbs from the 72 patients (mean age, 66.3±14.3 years). The subjects were classified into two groups as follows: a non-sarcopenia group (mean age, 65.8±13.5 years, n＝53), and a sarcopenia group (mean age, 67.8±15.8 years, n＝19). The thickness and echo intensity of the GM were measured using ultrasonography.</p><p>Results. Of 38 lower limbs in the 19-member sarcopenia group, 21 (55.3%) were positive for DVT. The prevalence of DVT significantly increased in the sarcopenia group as compared with the non-sarcopenia group (10.4%, p＜0.001). The GM echo intensity was significantly higher in the sarcopenia group than in the non-sarcopenia group. GM thickness was significantly greater in the non-sarcopenia group than in the sarcopenia group. In addition, tumor necrosis factor-α (TNF-α) levels were significantly higher in the sarcopenia group than in the non-sarcopenia group (p＝0.014).</p><p>Conclusions. Our study shows a significant increase in GM echo intensity, TNF-α levels, and DVT prevalence in the sarcopenia group, suggesting that cytokines are involved in the progression of sarcopenia and DVT.</p>

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