Tissue Distribution of Menaquinone-7 and the Effect of α-Tocopherol Intake on Menaquinone-7 Concentration in Rats
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- IKEDA Saiko
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- HANZAWA Fumiaki
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- TAKAHASHI Saki
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- SUZUKI Norie
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- SANO Kana
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- ODA Hiroaki
- Graduate School of Bioagricultural Sciences, Nagoya University
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- UCHIDA Tomono
- Department of Home Economics, Aichi Gakusen University
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Description
<p>We have reported that vitamin E intake lowers phylloquinone (PK) concentration in extrahepatic tissues of rats. In this study, we aimed to clarify the characteristic of the distribution of menaquinone-7 (MK-7), a vitamin K contained in fermented foods, by comparison with other vitamin K distributions and to clarify the effect of vitamin E intake on MK-7 concentration in rats. Rats were fed a vitamin K-free diet (Free group), a diet containing 0.75 mg PK/kg (PK group), a 0.74 mg menaquinone-4 (MK-4)/kg diet (MK-4 group), a 1.08 mg MK-7/kg diet (MK-7 group), or a 0.29 mg menadione (MD)/kg diet (MD group) for 16 wk. MK-7 mainly accumulated in the liver, spleen, and adrenal gland of the MK-7 group, although PK accumulated in the serum and all tissues of the PK group. Conversely, MK-4 was present in all tissues of the PK, MK-4, MK-7, and MD groups. MK-4 concentration in the serum, liver, adipose tissue, and spleen was higher in the MK-4 group than in the other groups; however, MK-4 concentration in the kidney, testis, tibia, and brain was lower in the MK-4 group than in the PK, MK-7, and MD groups. Next, vitamin E- and K-deficient rats were orally administered MK-7 with or without α-tocopherol. α-Tocopherol did not affect MK-7 or MK-4 concentration in the serum and various tissues. These results suggested that MK-7 is particularly liable to accumulate in the liver, and MK-7 concentration is not affected by vitamin E intake.</p>
Journal
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 64 (6), 391-398, 2018-12-31
Center for Academic Publications Japan
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Details 詳細情報について
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- CRID
- 1390564238060273280
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- NII Article ID
- 130007599141
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- NII Book ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL BIB ID
- 029399226
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- PubMed
- 30606961
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed