Effect of some vasoconstrictors on the local anesthetic efficiency of lidocaine by using the mental nerve block method in guinea pigs.

DOI IR
  • Masuda Yoshikatsu
    Department of Pharmacology, Iwate Medical University, School of Dentistry
  • Murai Shigeo
    Department of Pharmacology, Iwate Medical University, School of Dentistry
  • Hatakeyama Takeo
    Department of Pharmacology, Iwate Medical University, School of Dentistry
  • Yonekura Hideyo
    Department of Pharmacology, Iwate Medical University, School of Dentistry
  • Itoh Tadanobu
    Department of Pharmacology, Iwate Medical University, School of Dentistry

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  • モルモットのオトガイ神経ブロック法によるリドカインの局所麻酔効力におよぼす血管収縮薬の効果

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<p>It is known that the addition of vasoconstrictors to local anesthetic solution raises the pain threshold and prolongs the duration of anesthesia as compared to the anesthetic efficiencies of the soluttions without vasoconstrictors. In the present study, the depth and duration of anesthesia of a 2% lidocaine solution with norepinephrine (ranging from 1: 12,500 to 1: 50,000), phenylephrine (1: 5,000 to 1: 20,000) and methoxamine (1: 5,000 to 1: 20,000) were compared to those of the solution with epinephrine 1: 100,000, using the method of mental nerve block in guinea pigs as reported by Murai et al. The results obtained were summarized as follows: The depth and duration of anestesia of a 2% lidocaine solution increased markedly by the addition of norpeinephrine, phenylephrine and methoxamine to the solution, but the magnitude of such anesthetic efficiences were less than that of the solution with epinephrine 1: 100,000, except that the depth of anesthesia produced by the additon of methoxamine 1: 5,000 to the solution showed the same efficiency level as that of the solution with epinephrine 1: 100,000. However, no correlation was noted between the depth and duration of anesthesia of a 2% lidocaine solution, with or without the three vasoconstrictors.</p>

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