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- Omori-Miyake Miyuki
- Department of Microbiology and Immunology, Tokyo Women's Medical University
Bibliographic Information
- Other Title
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- アトピー性皮膚炎の表皮における構造の質的変化
- シンポジウム アトピー性皮膚炎の表皮における構造の質的変化
- シンポジウム アトピーセイ ヒフエン ノ ヒョウヒ ニ オケル コウゾウ ノ シツテキ ヘンカ
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Description
<p> Allergic diseases, including atopic dermatitis (AD) , are characterized by abundant production of Th2 cytokines. It was recently reported that IL-17A in the acute phase and IFNγ and IL-22 in the chronic phase both increased in the skin of AD. These cytokines were produced by immune cells that infiltrated into the lesional skin, resulting in the modification of structural protein expressions in the epidermis. This review summarizes (1) the effects of cytokines that are involved in development of AD on expression of structural proteins produced by epidermal keratinocytes and (2) the significance of keratin or desmosomal cadherin deficiency in increased expression of inflammatory cytokines and decreased expression of other structural proteins produced by epidermal keratinocytes. Challenges for the future will be to clarify the pathophysiology in AD based on changes in structural molecules and cytokines produced and cascades of molecular interactions causing different phases of pathophysiological changes in AD.</p>
Journal
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- Nihon Hifu Meneki Arerugy Gakkai Zasshi
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Nihon Hifu Meneki Arerugy Gakkai Zasshi 1 (1), 35-45, 2018-01-31
The Japanese Society for Cutaneous Immunology and Allergy
