STUDIES ON TERATOGENIC EFFECT OF SALICYLIC ACID AND ASPIRIN IN RATS AS RELATED TO FETAL DISTRIBUTION

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  • 経口投与サリチル酸およびアスピリンのラットに対する催奇形作用と胎仔移行に関する研究

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Pregnant rats received consecutive daily oral doses of salicylic acid and aspirin at dose levels of 75, 150 and 300 mg/kg from the 8 th to 14 th day of gestation, and their teratogenic effects were examined. In 300 mg/kg groups of both agents, the body weight gains were inhibited with the toxic symptoms such as salivation, piloerection, and some animals died within a few days after the beginning of the administration, and high fetal mortality prevailed. Various kinds of anomalies were observed with high incidence in the descendants of 150 mg/kg groups, especially in the salicylic acid group. It is concluded that these agents act teratogenically in the rats, and the teratogenic effect of salicylic acid may be considered as possibly due to direct action of the agent on the fetus, since a relative distribution of the agent was found in the fetus through the placental barrier.

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