Studies on Bredinin (II) Effect of Guanine Derivatives on Cytotoxicity and Teratogenicity of Bredinin in Rats
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- OKAMOTO Kyoko
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- HOSHINO Kyo
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- YOSHIDA Akihiko
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- KAWAI Yuichi
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- MAYUMI Tadanori
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- HAMA Takao
- Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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Abstract
Bredinin had teratogenic and embryo-lethal actions in mice and rats. These actions were reduced by the administration of guanosine to pregnant rats. In vitro, bredinin inhibited the proliferation of mouse embryo cells at a concentration of more than 10^<-7>M. The inhibitory effect was diminished by the addition of guanosine 5'-monophosphate (GMP) or guanosine to the culture medium. These results suggest that the teratogenic actions of bredinin are induced from a cytotoxic effect which is possibly due to bredinin competition with guanosine in fetal cells.
Journal
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- official journal of Congeital Anomalies Research Association of Japan
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official journal of Congeital Anomalies Research Association of Japan 20 (4), 359-364, 1980-12-30
The Japanese Teratology Society
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Details 詳細情報について
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- CRID
- 1390564238074838528
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- NII Article ID
- 110002727626
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- ISSN
- 24331503
- 00372285
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed