Morphological Analysis of Adult Common Marmoset (<i>Callithrix Jacchus</i>) Cochlea

DOI
  • Fujioka Masato
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University
  • Hikishima Keigo
    Okinawa Institute of Science and Technology
  • James Okano Hirotaka
    Division of Regenerative Medicine, Jikei University School of Medicine
  • Wakabayashi Ken-ichiro
    Department of Otorhinolaryngology, Kitasato Institute Hospital
  • Yamada Masayuki
    Department of Radiology, Fujita Health University
  • Oishi Naoki
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University
  • Hata Junichi
    Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute
  • Ogawa Kaoru
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University

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Other Title
  • 小型霊長類コモンマーモセットの側頭骨局所解剖に関する画像解析

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Description

<p>Model organisms are an indispensable tool for biomedical research. In order to conduct translational research that can have clinical applications, our group has been using a small non-human primate, common marmoset (Callithrix jacchus). Since whole genome database has already been established for common marmoset and novel bioengineering techniques to create genetically modified marmosets are also available, this species can be useful to establish disease models for pre-clinical research, especially for studying the genetic disorders where mouse models do not exist or for which the treatment differences among different species are known.</p><p>In this study, we performed morphological analyses of the temporal bone of marmosets. CT scan and 7-tesla MRI with or without cryogenic probe revealed that the morphology of the inner ear and ossicular chain of marmosets were similar to those of humans, although the size was relatively larger in comparison with the other surrounding structures. Mastoid air cells were replaced by a single bulla structure. These features indicate that the marmoset model is suitable for biomedical research, especially for modeling therapeutics with drug delivery into the inner ear with the post-auricular incision approach.</p>

Journal

  • Otology Japan

    Otology Japan 27 (5), 680-688, 2017

    Japan Otological Society

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