Application of <sup>13</sup>C-based Breath Test in Psychiatric Disorders

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  • Kunugi Hiroshi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan
  • Teraishi Toshiya
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan
  • Kajiwara Masahiro
    Laboratory of Natural Products Chemistry, Yokohama University of Pharmacy

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Other Title
  • <sup>13</sup>C呼気ガステストの精神疾患への応用
  • ¹³C呼気ガステストの精神疾患への応用
  • ¹ ³ C コキ ガステスト ノ セイシン シッカン エ ノ オウヨウ

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Abstract

<p>We introduced our studies on the possible clinical use of 13C-phynylalanine breath test and 13C-tryptophan breath test in psychiatric disorders. By the phenylalanine test, we detected decreased metabolism of phenylalanine in patients with schizophrenia. In the tryptophan test, on the other hand, we obtained evidence supporting the enhanced metabolism of the tryptophan-kynurenine pathway in patients with major depressive disorder. Collectively, these 13C-labelled breath tests may be useful in the diagnosis and subtyping psychiatric disorders such as schizophrenia and depressive disorder.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 68 (2), 49-58, 2019-02-15

    Japan Radioisotope Association

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