Degenerative Myelopathy in a Shetland Sheepdog

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  • GODA Mai
    MIYA ANIMAL HOSPITAL
  • MIYA Yutaka
    MIYA ANIMAL HOSPITAL
  • MIE Keiichiro
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • CHAMBERS James
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, Tokyo University
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, Tokyo University
  • AKIYOSHI Hideo
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University

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Other Title
  • 変性性脊髄症と診断したシェットランド・シープドッグの1例
  • 変性性脊髄症と診断したシェットランド・シープドックの1例
  • ヘンセイセイ セキズイショウ ト シンダン シタ シェットランド ・ シープドック ノ 1レイ

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Abstract

<p>A spayed, female Shetland sheepdog diagnosed with Hansen type II intervertebral disc disease showed progressive ataxia and loss of bark. Superoxide dismutase (SOD) 1 mutation analysis confirmed homozygous mutation. The dog died from insufficient breathing on day 859, necropsy was carried out, and histology of the brain and spinal cord was examined. Histopathological examinations revealed myelin loss, axonal degeneration, and diffuse proliferation of astrocytes in the spinal white matter, as well as neuronal loss and chromatolysis of remaining neuronal cells in the ventral horn. These lesions almost conform to those of canine degenerative myelopathy (DM). For Shetland sheepdogs with homozygous SOD1 mutation and symptoms of progressive ataxia, canine DM should be considered as a possible differential diagnosis.</p>

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