市販局所外用剤(軟膏剤/クリーム剤/外用液剤)の押出し質量と容器に関する調査研究―外用剤のFTU/一円玉径質量と適正使用―

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タイトル別名
  • Psychorheological Research on Container Development for Topical Drug Formulation

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<p>To ensure accurate application/dosing for patients, one fingertip unit press-out dispensing of ointments or creams is effective for knowing the exact quantity dispensed. Further, the press-out for a 1-yen diameter unit of topically applied liquid is also effective for accurate use with respect to quantity. To confirm the suitable topical usage for patients, we used multivariate analysis to investigate the relationship between the physicochemical properties of many commercial products (ointments, creams, and lotions) contained in tubes or bottles, and the exact quantity pressed out from these containers. We observed that not only the diameter of the tube opening but also the specific physicochemical properties of the products inside the tubes/bottles were closely related to the exact quantity pressed out. It is accordingly considered that for topical formulations, tube/bottle design based on the physicochemical properties of the contents is important for ensuring their accurate use.</p>

収録刊行物

  • 薬剤学

    薬剤学 72 (6), 359-367, 2012

    公益社団法人 日本薬剤学会

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