Communication to the Editor : Palladium-Catalyzed C-H Heteroarylation of 2,5-Disubstituted Imidazoles
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- Togo Takaya
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Sohma Youhei
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Kuninobu Yoichiro
- Institute for Materials Chemistry and Engineering, Kyushu University
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- Kanai Motomu
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
書誌事項
- タイトル別名
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- Palladium-Catalyzed C–H Heteroarylation of 2,5-Disubstituted Imidazoles
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<p>We developed a palladium-catalyzed C–H N-heteroarylation of N-protected-2,5-disubstituted imidazoles at the C4-position using N-heteroaryl halides as a coupling partner. Intensive reaction condition screening led us to identify fluorinated bathophenanthroline 7 as the optimum ligand for the palladium catalyst. This reaction will enhance lead optimization of drug candidates by facilitating the synthesis of heterobiaryl compounds containing an imidazole ring.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 67 (3), 196-198, 2019-03-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390564238077869824
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- NII論文ID
- 130007607157
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 029543701
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- PubMed
- 30282839
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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- 使用不可