Systematic Analysis of Selective Bactericidal Activity of Fatty Acids against Staphylococcus aureus with Minimum Inhibitory Concentration and Minimum Bactericidal Concentration
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- Watanabe Takamasa
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
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- Yamamoto Yoshiaki
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
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- Miura Maki
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
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- Konno Hiroyuki
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
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- Yano Shigekazu
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
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- Nonomura Yoshimune
- Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
書誌事項
- タイトル別名
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- Systematic Analysis of Selective Bactericidal Activity of Fatty Acids against <i>Staphylococcus aureus</i> with Minimum Inhibitory Concentration and Minimum Bactericidal Concentration
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説明
<p>Bacterial flora on the skin surface contains Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) which causes rough skin and atopic dermatitis and enhances innate immunity, respectively. In this study, minimum inhibitory concentration (MIC) was evaluated for six saturated fatty acids and two unsaturated fatty acids against S. aureus and S. epidermidis. The antimicrobial behavior in the liquid medium was categorized into three groups. The first was the selective antibacterial activity group comprising myristic acid (C14:0 fatty acid), palmitoleic acid (C16:1 fatty acid), and oleic acid (C18:1 fatty acid) and preferentially displayed antimicrobial activity for S. aureus (group 1). C16:1 fatty acid displayed high antimicrobial activity only for S. aureus. The second was the non-selective antibacterial activity group which displayed antibacterial activity for both Staphylococci (group 2). Caprylic acid (C8:0 fatty acid), capric acid (C10:0 fatty acid), and lauric acid (C12:0 fatty acid) comprised group 2. The third was the nonantibacterial activity group which did not show significant antimicrobial activity (group 3). Bactericidal activities were confirmed for C12:0 fatty acid and C16:1 fatty acid by evaluating the minimum bactericidal concentration (MBC) on the agar medium. C12:0 fatty acid displayed non-selective bactericidal behavior against S. aureus and S. epidermidis when the fatty acid concentration was above 250 μg mL–1. These findings suggest that C16:1 fatty acid has the potential to be used as a detergent in skin care and medical products because it can selectively kill only S. aureus.</p>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 68 (3), 291-296, 2019
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390564238078507904
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- NII論文ID
- 130007606004
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 029540066
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- PubMed
- 30760667
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可