Successful treatment with preceding low-intensity chemotherapy in a primary mediastinal large B cell lymphoma patient diagnosed at 11 weeks of pregnancy

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  • HATTORI Daiki
    Department of Hematology, Kawaguchi Municipal Medical Center Department of Clinical Oncology and Hematology, The Jikei University School of Medicine
  • YAHAGI Yuichi
    Department of Hematology, Kawaguchi Municipal Medical Center
  • URYU Hideki
    Department of Clinical Oncology and Hematology, The Jikei University School of Medicine
  • HOSOBA Rika
    Department of Clinical Oncology and Hematology, The Jikei University School of Medicine
  • MOMOKI Mamiko
    Department of Clinical Oncology and Hematology, The Jikei University School of Medicine
  • NAGAO Riku
    Department of Hematology, Kawaguchi Municipal Medical Center
  • YAMAZAKI Hiroyuki
    Department of Hematology, Kawaguchi Municipal Medical Center

Bibliographic Information

Other Title
  • 妊娠11週に診断し低強度治療先行が奏効した縦隔原発大細胞型B細胞リンパ腫
  • 症例報告 第8回日本血液学会関東甲信越地方会 奨励賞 妊娠11週に診断し低強度治療先行が奏効した縦隔原発大細胞型B細胞リンパ腫
  • ショウレイ ホウコク ダイ8カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ショウレイショウ ニンシン 11シュウ ニ シンダン シ テイキョウド チリョウ センコウ ガ ソウコウ シタ ジュウカク ゲンパツ ダイ サイボウガタ B サイボウ リンパシュ

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Abstract

<p>At 11 weeks of pregnancy, a 31-year-old woman presented with an anterior chest tumor and dyspnea. A computed tomography (CT) scan revealed a bulky tumor in the mediastinum that compressed the trachea. She underwent a CT-guided needle biopsy and was diagnosed with primary mediastinal large B cell lymphoma. She was initially treated with steroid pulse therapy, followed by vincristine-cyclophosphamide-prednisolone (VCP) therapy, which relieved her dyspnea. She was then treated with 8 cycles of rituximab-cyclophosphamide-doxorubicin-vincristine-prednisolone (R-CHOP) therapy at 13 weeks of pregnancy. The patient delivered her baby at 35 weeks and 6 days of pregnancy. Despite the preterm delivery and other than the low-birth weight, her baby was healthy. A positron emission tomography-CT scan showed that a complete metabolic response was achieved. Our case report suggests that steroid pulse and VCP therapy followed by R-CHOP therapy is safe and effective for patients with malignant lymphoma in their first trimester of pregnancy.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (2), 112-117, 2019

    The Japanese Society of Hematology

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