Carotid Intima-Media Thickness in Patients with Ankylosing Spondylitis: A Systematic Review and Updated Meta-Analysis
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- Yuan Yaping
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Yang Jiajia
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Zhang Xu
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Han Renfang
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Chen Mengya
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Hu Xingxing
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Ma Yubo
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Wu Meng
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Wang Mengmeng
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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- Xu Shengqian
- Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University
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- Pan Faming
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University
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説明
<p>Aim: Inflammatory arthritis (IA) diseases are relevant with subclinical atherosclerosis, but the data in ankylosing spondylitis (AS) were inconsistent. Therefore, we performed this meta-analysis to explore the relationship between the marker of subclinical atherosclerosis (carotid intima-media thickness (IMT)) and AS.</p><p>Methods: We performed a systematic literature review using PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM) databases up to March 2018. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to assess the association between carotid IMT and AS. Subgroup analysis, sensitivity analysis, and meta-regression were applied to explore the sources of heterogeneity, and publication bias was calculated to access the quality of pooled studies.</p><p>Results: A total of 24 articles were collected. The carotid IMT was significantly increased in AS compared with healthy controls (SMD=0.725, 95% CI=0.443–1.008, p＜0.001). Subgroup analyses showed the Bath Ankylosing Spondylitis Activity Index (BASDAI) was the source of heterogeneity. Notably, IMT was not significantly increased in those studies that included ＞50% patients treated with anti-TNF. Meta-regression revealed severe inflammation status (BASDAI and C-reactive protein (CRP)) could significantly impact carotid IMT in AS.</p><p>Conclusions: Carotid IMT was significantly increased in patients with AS compared with healthy controls, which suggested subclinical atherosclerosis is related to AS.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 26 (3), 260-271, 2019-03-01
一般社団法人 日本動脈硬化学会