Phenotype-driven strategies for genomic medicine in clinical care for patients with hereditary hearing loss

DOI
  • Matsunaga Tatsuo
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center Department of Otolaryngology, National Hospital Organization Tokyo Medical Center
  • Kaga Kimitaka
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center Department of Otolaryngology, National Hospital Organization Tokyo Medical Center Speech-Language and Hearing Center, International University of Health and Welfare
  • Mutai Hideki
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center
  • Nara Kiyomitsu
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center
  • Minami Shujiro B.
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center Department of Otolaryngology, National Hospital Organization Tokyo Medical Center
  • Yamamoto Nobuko
    Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center Department of Otolaryngology, National Hospital Organization Tokyo Medical Center
  • Fujioka Masato
    Department of Otolaryngology, Keio University School of Medicine
  • Ogawa Kaoru
    Department of Otolaryngology, Keio University School of Medicine

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Other Title
  • 臨床像起点の遺伝性難聴診療の確立

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Abstract

<p>Patients with hereditary hearing loss usually visit hospitals as one of many patients with hearing loss without clues of genetic causes. Consideration on possibilities of genetic causes based on clinical pictures will improve quality of clinical care by choosing appropriate tests, examinations and therapy. Patients who are provided with such clinical information conformed to the clinical condition, especially before genetic tests, are likely to have clinical care without troubles and less psychological stresses. Here, we describe such phenotype-driven strategies for genomic medicine in clinical care for patients with hereditary hearing loss by showing representative genetic causes and clinical pictures.</p>

Journal

  • Otology Japan

    Otology Japan 28 (2), 65-69, 2018

    Japan Otological Society

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