Lymphoscintigraphy for Sentinel Lymph Nodes in Breast Cancer : Visualization Standard and Optimum Timing

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  • Lymphoscintigraphy for Sentinel Lymph Nodes in Breast Cancer
  • Visualization Standard and Optimum Timing

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Lymphoscintigraphy is an effective method for detecting sentinel lymph nodes (SLNs). However, the amount and timing of the Tc-99m tin colloid accumulate to the SLN is not uniform, and standard for scintigraphic imaging of SLNs before breast cancer resection have not been established. To evaluate the visualization standard for SLN scintigraphy in breast cancer patients, we determined visualization standard for SLN by phantom study. The visualization standard was over 15 counts from background. We assessed the optimum timing of SLN visualization in 89 breast cancer patients. Tc-99m tin colloid was injected around the tumor on the day before surgery, and SLN scintigraphy was conducted 1 hour, 2 hours, 3 hours and 18 hours after injection. Detection rate after 1, 2, 3 and 18 hours were 80.4%, 90.0%, 97.3% and 97.3% respectively. When Tc-99m tin colloid was injected intradermally around the tumor of breast cancer patients, sufficient visualization was obtained in scintigraphy at 3 hours after injection.

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