COMPARISON OF LATE ADVERSE EVENTS AFTER ENDOSCOPIC SPHINCTEROTOMY VERSUS ENDOSCOPIC PAPILLARY LARGE BALLOON DILATION FOR COMMON BILE DUCT STONES: A PROPENSITY SCORE-BASED COHORT ANALYSIS

DOI
  • MARUTA Akinori
    First Department of Internal Medicine, Gifu University Hospital.
  • IWASHITA Takuji
    First Department of Internal Medicine, Gifu University Hospital.
  • UEMURA Shinya
    First Department of Internal Medicine, Gifu University Hospital.
  • YOSHIDA Kensaku
    First Department of Internal Medicine, Gifu University Hospital.
  • IWATA Keisuke
    Department of Gastroenterology, Gifu Prefectural General Medical Center.
  • MUKAI Tsuyoshi
    Department of Gastroenterology, Gifu Municipal Hospital.
  • DOI Shinpei
    Department of Gastroenterology, Teikyo University Mizonokuchi Hospital.
  • YASUDA Ichiro
    Department of Gastroenterology, Teikyo University Mizonokuchi Hospital.
  • IMAI Kenji
    First Department of Internal Medicine, Gifu University Hospital.
  • SHIMIZU Masahito
    First Department of Internal Medicine, Gifu University Hospital.

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Other Title
  • 総胆管結石に対するESとEPLBDの晩期偶発症における比較検討　a propensity score-based cohort analysis

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<p>Background and Aim: Endoscopic sphincterotomy (ES) is a standard procedure for the treatment of common bile duct stones (CBDS). Endoscopic papillary large balloon dilation (EPLBD) is emerging as an effective method to treat difficult CBDS, providing several advantages over ES without increasing early adverse events (AE). However, the late AE of EPLBD have not yet been well studied. The aim of the present study was to compare late AE after EPLBD versus ES for the treatment of CBDS using a propensity score-based cohort analysis.</p><p>Methods: Propensity score matching was introduced to reduce the possible bias in baseline characteristics between two treatment groups and formed the matched cohort including 240 patients. Primary endpoint was cumulative as well as estimated 1-year and 3-year late AE rates. Secondary outcome was the incidence of early AE.</p><p>Results: Cumulative late AE rates were 12.5% and 16.7% in the ELPBD and ES groups (P=0.936) with a median follow-up period of 915.5 and 1,544.5 days, respectively. Estimated 1-year and 3-year late AE rates were 8.4% and 13.1% in the EPLBD group and 5.0% and 15.0% in the ES group, respectively. In multivariate analysis, ≥two procedures were identified as independent risk factors for late AE. Overall early AE rate did not differ between the groups.</p><p>Conclusion: In the present study, late AE rate after EPLBD showed no significant difference compared with that after ES, which had a relatively long follow-up period. Therefore, EPLBD could be used for the treatment of CBDS, if CBDS are considered difficult to treat. Clinical Trial Registry: UMIN000027798.</p>

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Details 詳細情報について

  • CRID
    1390564238082385152
  • NII Article ID
    130007616779
  • DOI
    10.11280/gee.61.309
  • ISSN
    18845738
    03871207
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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