Effects of antiepileptic monotherapy on hematological and biochemical parameters

DOI Web Site 参考文献28件
  • Ohta Kaseya
    Onda-Daini Hospital
  • Sumi Yuki
    Department of Respiratory and Nervous System Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Akaza Miho
    Department of Respiratory and Nervous System Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Yanagisawa Eriko
    Medical Technology, School of Health Care Sciences, Faculty of Medicine, Tokyo Medical and Dental University
  • Yoshimura Yuri
    Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Hara Keiko
    Hara Clinic Department of Respiratory and Nervous System Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Inaji Motoki
    Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Maehara Taketoshi
    Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

書誌事項

公開日
2019
資源種別
journal article
DOI
  • 10.3805/eands.11.1
公開者
一般社団法人 日本てんかん学会

この論文をさがす

説明

<p>Purpose: Severe cytopenia and liver dysfunction are characterized as antiepileptic drug (AED) adverse effects dependent upon an idiosyncrasy. However, in clinical practice, we often find hemato-logical and biochemical changes during AED treatment with causes other than an idiosyncrasy. This study aims to investigate the effect of antiepileptic monotherapy on hematological and biochemical parameters.</p><p>Methods: We retrospectively recruited 480 patients untreated with AED at baseline. Changes in hematological and biochemical parameters before and after initiation of medication were investigated, and correlation with plasma concentrations of AED was analyzed.</p><p>Results: Sixty-six of 480 patients treated with carbamazepine (CBZ: n = 27), sodium valproate (VPA: n = 19) or levetiracetam (LEV: n = 20) monotherapy were eventually selected for analysis. After CBZ treatment, decreased white blood cell (WBC) count and increased gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities were recorded at high frequencies. Decreased WBC count tended to correlate with elevated serum CBZ level. Elevated GGT activity was observed in all patients treated with CBZ. In patients treated with VPA, platelet (PLT) counts decreased. In patients treated with LEV, there were no significant differences in the measured parameters before and after medication.</p><p>Discussion: We considered that the reduction in WBC count might be dose-dependently related to AEDs. Elevated GGT activity was observed in all patients treated with CBZ, but the average increase in GGT activity was 35.19 ± 33.08 U/L. In patients undergoing VPA treatment, decreased PLT counts were also observed at high frequency. Thus, hematological and biochemical parameters should be closely monitored in patients receiving AED, especially in patients treated with high doses of AEDs.</p>

収録刊行物

  • Epilepsy & Seizure

    Epilepsy & Seizure 11 (1), 1-13, 2019

    一般社団法人 日本てんかん学会

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