From neuronal circuit to pathology of mental disorders

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  • Hikida Takatoshi
    Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University

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  • 神経回路から精神疾患病態へ
  • シンケイ カイロ カラ セイシン シッカン ビョウタイ エ

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Abstract

Mental disorders are complex diseases involving both genetic and environmental factors. We developed mutant DISC1 transgenic mice as a genetic model of mental disorders, which abnormality became worse by environmental stress in the prenatal or adolescent period. We also found that two distinct direct and indirect striatal pathways have the distinct roles in cognitive learning, indicating that the circuit abnormality reflects on the cognitive deficits of mental disorders. Revealing pathology of mental disorders from analysis of neural circuit functions in psychiatric disease models is expected.

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