A Case of Pediatric Acute Lymphoblastic Leukemia Diagnosed with Hypopyon as Initial Symptom

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  • Takahashi Nobuhisa
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Sano Hideki
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Mochizuki Kazuhiro
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Kobayashi Shogo
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Ohara Yoshihiro
    Department of Pediatric Oncology, Fukushima Medical University Hospital
  • Furuta Minoru
    Department of Ophthalmology, Fukushima Medical University
  • Kikuta Atsushi
    Department of Pediatric Oncology, Fukushima Medical University Hospital

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Other Title
  • 前房蓄膿を初発症状として診断された小児急性リンパ性白血病の1例

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Abstract

<p>Hypopyon commonly manifests in infections and autoimmune diseases such as Behcet’s disease, but rarely occurs in patients with acute leukemia. In this case, a 5-year-old girl was diagnosed as having hypopyon by a local physician and referred to our hospital for a definitive diagnosis. She was diagnosed as having B precursor acute lymphoblastic leukemia (ALL), with central nervous system invasion. The patient underwent iridectomy to decrease the intraocular pressure in the left eye, and ALL cells were observed in the iris. Following treatment, she remained in complete remission for 7 years. Hypopyon in patients with acute leukemia is often observed at the time of relapse, but is rarely detected at the initial stage. Regular follow-up for recurrence is necessary owing to the limited transport of anticancer drugs to the eyes.</p>

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