A Study of the Effect of Diet and Physical Activity on Bone Metabolism

Ishimi Yoshiko

doi:10.4327/jsnfs.72.71

Bibliographic Information

Other Title

骨代謝における食事と運動の有用性に関する研究
骨代謝における食事と運動の有用性に関する研究(平成30年度日本栄養・食糧学会学会賞受賞)
コツタイシャニオケルショクジトウンドウノユウヨウセイニカンスルケンキュウ(ヘイセイ 30ネンドニホンエイヨウ・ショクリョウガッカイガッカイショウジュショウ)
(JSNFS Award for Excellence in Research (2018))
(平成30年度日本栄養・食糧学会学会賞受賞)

Search this article

Description

<p>Various health plans have been proposed in Japan in order to extend healthy life expectancy. We have accumulated scientific evidence related to lifestyle factors that are beneficial for preservation of bone health. First, we have screened nutrients and food components that affect bone metabolism using osteoblast and osteoclast formation assay systems. Vitamin A and vitamin K derivatives as well as soybean isoflavones appeared to be likely candidates. Since isoflavones have been a focus of attention because of their weak estrogenic activity as phytoestrogens, we have assessed the safety and efficacy of isoflavones, and their cooperative effects with exercise on bone metabolism in postmenopausal healthy Japanese women as well as an animal model of osteoporosis. On the other hand, we have demonstrated that undigestible carbohydrates stimulate the production of equol, which seems to be an active form of isoflavone, from isoflavone daidzein by gut microbiota. Finally, a dietary pattern for preservation of healthy bone has been proposed. These results are considered to be helpful for devising measures for the elderly in health plans.</p>

Journal

Nippon Eiyo Shokuryo Gakkaishi

Nippon Eiyo Shokuryo Gakkaishi 72 (2), 71-77, 2019

Japan Society of Nutrition and Food Science

Keywords

Details 詳細情報について

Export