Influence of Folic Acid Restriction on Body Composition and Bone Mineral Density in Ovariectomized Rats Fed a High-fat Diet

DOI Web Site
  • NAKAOKA Kanae
    Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women’s University
  • YAMADA Asako
    Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women’s University
  • NODA Seiko
    Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women’s University
  • YAMADA Momoko
    Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women’s University
  • GOSEKI (SONE) Masae
    Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women’s University

Bibliographic Information

Other Title
  • 卵巣摘出ラットにおける高脂肪食摂取時の葉酸制限が体組成および骨密度に及ぼす影響
  • ランソウ テキシュツ ラット ニ オケル コウシボウショク セッシュジ ノ ヨウサン セイゲン ガ カラダ ソセイ オヨビ コツミツド ニ オヨボス エイキョウ

Search this article

Abstract

<p>  This study investigated the influence of folic acid restriction on body composition and bone mineral density in ovariectomized (OVX) rats fed a high-fat diet. Female Sprague-Dawley rats (13 weeks old) were OVX or sham-operated (Sham). The OVX rats were divided into four groups: a basic control diet (OVX-Cont.), a basic control diet with folic acid restriction (OVX-FR), a high-fat diet (OVX-F), and a high-fat diet with folic acid restriction (OVX-HFR). At 28 days after starting the experimental diet, ovariectomy significantly increased the weight of fat and significantly decreased the bone mineral density (BMD) of vertebrae and femora. On the basis of two-way ANOVA, the high-fat diet significantly increased the body fat in the OVX groups. A significant interaction between folic acid restriction and the high-fat diet was observed for the femoral cancellous BMD in the OVX groups, and the femoral cancellous BMD was significantly lower in the OVX-HFR group compared with the OVX-F group. In the present study, a high-fat diet with folic acid restriction decreased the femoral cancellous BMD in OVX rats. An adequate intake of folic acid is necessary in order to maintain bone health and prevent osteoporosis.</p>

Journal

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top