[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Anticancer Effect of Alkaline Reduced Water(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Science)

DOI
  • LEE Kyu-Jae
    Dept. of Parasitology, Wonju College of Medicine, Yonsei Univ.:Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei Univ.
  • PARK Seung-Kyu
    Dept. of Parasitology, Wonju College of Medicine, Yonsei Univ.:Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei Univ.
  • KIM Jae-Won
    Dept. of Parasitology, Wonju College of Medicine, Yonsei Univ.
  • KIM Gwang-Young
    Dept. of Parasitology, Wonju College of Medicine, Yonsei Univ.
  • RYANG Young-Suk
    Dept. of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei Univ.
  • KIM Geun-Ha
    Dept. of Parasitology, Wonju College of Medicine, Yonsei Univ.
  • CHO Hyun-Cheol
    Dept. of Microbiology, Wonju College of Medicine, Yonsei Univ.
  • KIM Soo-Kie
    Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei Univ.:Dept. of Microbiology, Wonju College of Medicine, Yonsei Univ.
  • KIM Hyun-Won
    Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei Univ.:Dept. of Biochemistry, Wonju College of Medicine, Yonsei Univ.

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Abstract

Certain minerals can produce alkaline reduced water with high pH and low oxidation-reduction potential (ORP) when dissolved in water. Alkaline reduced water (ARW) showed significant anticancer effect. When B16 melanoma cells were inoculated subcutaneously and intra-peritoneally, C56BL/6 mice fed with ARW showed tumor growth delay and the survival span was significantly lengthened. ARW also showed the inhibition of metastasis by reducing the numbers of B16 melanoma colonies when injected through tail vein. The amount of reactive oxygen species (ROS) was very reduced when fed with ARW except for spleen, which is a major organ for immunity. Even for normal mice, ARW intake invoked systemic cytokines, such as, Th1 (IFN-γ, IL-12) and Th2 (IL-4, IL-5), suggesting strong immuno-modulation effect. Both ROS scavenging effect and immuno-modulation effect might be responsible for anticancer effect of alkaline reduced water.

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