A case of myeloid sarcoma with initial symptoms in the oral cavity

YAJIMA Shosuke, YASUI Takazumi, KARUBE Takeshi, SATO Hitoshi, ASODA Seiji, ONIZAWA Katsuhiro

doi:10.5794/jjoms.65.229

<p>We report a case of myeloid sarcoma that occurred in the gingiva and buccal region and progressed to acute myeloid leukemia. An 82-year-old man was referred to our hospital because to undergo examination of right cheek and submandibular swelling. At presentation, swelling of the gingiva of the right lower molar and a tumor measuring 20 mm in diameter were noted in the right cheek region. We performed an incisional biopsy of the mass in the right buccal region, and the histopathological diagnosis was myeloid sarcoma. Therefore, we referred the patient to the department of hematology in our hospital. Considering the patient’s age, we performed observation without immediate therapeutic intervention. Blast cells appeared in peripheral blood after 6 months, which indicated the development of acute myeloid leukemia. Although we started remission induction therapy with a CAG regimen (cytarabine, aclarubicin, granulocyte colony-stimulating factor), complete remission was not achieved. Leukocytes and blast cells increased in peripheral blood, and the patient died 9 months after starting primary treatment.</p>

A case of myeloid sarcoma with initial symptoms in the oral cavity

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